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Original Research

Open Access

Dilemma in the Treatment of a Central Giant Cell Granuloma

  • Astrid Toferer1,*,
  • Astrid Truschnegg2
  • Lisa Merl3
  • Bernadette Liegl- Atzwanger4
  • Wolfgang Zemann1
  • Alfred Beham3

1Division of Oral and Maxillofacial Surgery, Medical University of Graz

2Division of Dental Medicine and Oral Health, Medical University of Graz

3,Medical University of Graz

4Program of Soft tissue and Bone Pathology, Division of Diagnostic and Research Pathology, Medical University of Graz

5,

DOI: 10.17796/1053-4625-45.5.8 Vol.45,Issue 5,November 2021 pp.337-340

Published: 05 November 2021

*Corresponding Author(s): Astrid Toferer E-mail: astrid.hiebaum@medunigraz.at

Abstract

Management of central giant cell granuloma (CGCG) presents a clinical challenge. While eradicating a lesion known for its high recurrence rate calls for radical surgical approaches, these cause significant esthetic and functional impairment. We present an eight-year-old boy suffering from an extraordinarily large CGCG expanding into the mandible and base of the mouth in the whole anterior region. Combined treatment with surgical intervention and corticosteroid application was successfully applied, and all six attached dental germs could be preserved. Different approaches for clinical management in pediatric cases are discussed.

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Astrid Toferer,Astrid Truschnegg,Lisa Merl,Bernadette Liegl- Atzwanger,Wolfgang Zemann,Alfred Beham. Dilemma in the Treatment of a Central Giant Cell Granuloma. Journal of Clinical Pediatric Dentistry. 2021. 45(5);337-340.

References

1. Raubenheimer E., Jordan R.C. Giant cell lesions and bone cysts. In: El-Naggar AK, Chan JKC, Grandis JR, eds. WHO classification of head and neck tumors. 4th ed. Lyon: IARC Press; 256-258, 2017

2. Schreuder W.H., Van den Berg H., Westermann A.M., Peacock Z.S., De Lange J. Pharmacological and surgical therapy for the central giant cell granuloma: A long-term retrospective cohort study. J Craniomaxillofac Surg, 2017; 45(2): 232-243.

3. De Lange J., Van den Akker H.P., Veldhuijzen van Zanten G.O., Engelshove H. A., Van den Berg H., Klip H. Calcitonin therapy in central giant cell granuloma of the jaw: A randomized double-blind placebo-controlled study. Int J Oral Maxillofac Surg, 2006; 35(9):791-795.

4. Gomes C.C., Gayden T., Bajic A., et al. TRPV4 and KRAS and FGFR1 gain-of-function mutations drive giant cell lesions of the jaw. Nature communications ,2018; 1:4572.

5. Chrcanovic B.R., Gomes C.C., Gomez R.S. Central giant cell lesion of the jaws: An updated analysis of 2270 cases reported in the literature. J Oral Pathol Med, 2018; 47(8):731-739.

6. Tosco P., Tanteri G., Iaquinta C., et al. Surgical treatment and reconstruction for central giant cell granuloma of the jaws: A review of 18 cases. J Cranio-maxillofac Surg, 2009; 37(7):380-387.

7. Nogueira R.L., Teixeira R.C., Cavalcante R.B., Ribeiro R.A., Rabenhorst S.H. Intralesional injection of triamcinolone hexacetonide as an alternative treatment for central giant-cell granuloma in 21 cases. Int J Oral Maxillofac Surg , 2010; 39(12):1204-1210.

8. Goldman K.E., Marshall M.K., Alessandrini E., Bernstein M.L. Compli-cations of alpha-interferon therapy for aggressive central giant cell lesion of the maxilla. Oral Surg Oral Med Oral Pathol Oral Radiol Endod , 2005; 100(3):285-291.

9. Ng V.Y., Davidson D.J., Kim E.Y., Pollack S.M., Conrad E.U., Jones R.L. The multidisciplinary management of giant cell tumor of bone. Expert Rev Anticancer Ther , 2014; 14(7):783-790.

10. Vered M., Buchner A., Dayan D. Immunohistochemical expression of glucocorticoid and calcitonin receptors as a tool for selecting therapeutic approach in central giant cell granuloma of the jawbones. Int J Oral Maxil-lofac Surg, 2006; 35(8):756-760.

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